Researchers for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) plan to map the DNA of 800 people who are taking part in a study of the causes of memory and cognitive loss, according to various press reports this week.
The University of California at Los Angeles (UCLA) issued a press release on this project on Tuesday.
According to that release, since 2004 UCLA’s Laboratory of Neuro Imaging (LONI) has been receiving, organizing, archiving and disseminating data generated by ADNI, which is a worldwide effort by scientists to define the progression of Alzheimer’s disease.
“That stream of data will now turn into a flood, as LONI partners with an ambitious public–private effort to dig deeper into the causes of this devastating disease by obtaining the whole-genome sequencing of the more than 800 people enrolled in ADNI — the largest cohort of individuals related to a single disease,” the press release stated.
This next stage of research will generate at least 165 terabytes of new genetic data, an amount equivalent to the information contained in 165,000 entire copies of the Encyclopedia Britannica.
“This effort, involving almost 60 sites around the country, is the best chance we have for understanding this brutal disease,” LONI director Arthur Toga, a UCLA professor of neurology and one of the collaborators on the management of the sequencing efforts, said in a statement.
“We collect vast amounts of imaging, cognitive and biosample data from hundreds of subjects with Alzheimer’s disease, those at risk, and controls,” Toga said. “One of the more unique aspects of this study is that all data are shared with any scientist, without embargo. We have already engaged many scientists around the world with this open access.”
This new genome project is a major expansion of ADNI, which now enrolls people with Alzheimer’s disease, mild cognitive impairment and normal cognition who have agreed to be studied in great detail over time. The Study’s goal is to identify and understand markers of the disease with the hope of improving early diagnosis and accelerating the discovery of new treatments.
All of the ADNI data continues to flow into UCLA’s LONI, including detailed, long-term assessments of neuropsychological measures, standardized structural and functional imaging, and precise biomarker measures from blood and spinal fluid.
Now, the ADNI participants’ entire genome sequences, which determine all 6 billion letters in an individual’s DNA in one comprehensive analysis, will be added to that storehouse of knowledge.
Once the sequences are completed — roughly 16 weeks after the sequencing project starts — the raw data will be available to scientists around the globe “to mine for novel targets for risk-assessment, new therapies and much-needed insights into the causes of Alzheimer’s,” according to the press release.
All of the information from ADNI has always been made freely available, without delay, to scientists; to date, this has resulted in more than 500 scientific manuscripts.
ADNI is a public–private research project led by the National Institutes of Health with private sector support through the Foundation for NIH. Launched in 2004, ADNI’s public–private funding consortium includes pharmaceutical companies, science-related businesses and nonprofit organizations, including the Alzheimer’s Association and the Northern California Institute for Research and Education.
The ADNI whole-genome sequencing is being funded with $2 million through a partnership between the Alzheimer’s Association and the nonprofit Brin Wojcicki Foundation, a charitable organization created by Anne Wojcicki, founder of the online genetics firm 23andMe, and her husband, Sergey Brin, co-founder of Google.
“Sequencing the ADNI participants and making the genetic data immediately available to researchers around the world will significantly improve our understanding and approach to Alzheimer’s disease,” Anne Wojcicki said in a statement . “The ADNI team and the Alzheimer’s Association are impressive in their ability to quickly make decisions that are truly in the best interest of people with Alzheimer’s.”
“Linking these deep-sequencing data with imaging and other data may help solve the puzzles in Alzheimer’s that still vex us,” Toga said. “Certainly, a more complete picture will emerge, hopefully leading to effective therapies.”
LONI, which seeks to improve understanding of the brain in health and disease, has developed advanced computational algorithms and scientific approaches for the comprehensive and quantitative mapping of brain structure and function. It is part of the UCLA Department of Neurology, which encompasses more than a dozen research, clinical and teaching programs. The department ranks in the top two among its peers nationwide in National Institutes of Health funding.