Brain abnormalities present at birth and others that develop over time may be linked to migraines, according to a new study just published online in the journal Radiology.
First of all, let’s define a migraine: It is a throbbing headache sometimes accompanied by nausea, vomiting and sensitivity to light. More than 300 million people suffer from migraines worldwide, according to the World Health Organization.
Prior studies on migraine patients have shown atrophy of cortical regions in the their brain related to pain processing, possibly due to chronic stimulation of those areas, according to a press release issued Tuesday by the Radiological Society of North America. “Cortical” refers to the outer layer of the brain, the cortex.
Keep with me here. A lot of that prior research has relied on voxel-based morphometry, which estimates the brain’s cortical volume. In the latest study, Italian researchers instead used a surface-based MRI method to measure cortical thickness.
“For the first time, we assessed cortical thickness and surface area abnormalities in patients with migraine, which are two components of cortical volume that provide different and complementary pieces of information,” Dr. Massimo Filippi said in a statement.
“Indeed, cortical surface area increases dramatically during late fetal development as a consequence of cortical folding, while cortical thickness changes dynamically throughout the entire life span as a consequence of development and disease,” he said.
Filippi is director of the Neuroimaging Research Unit at the University Ospedale San Raffaele and professor of neurology at the University Vita-Salute’s San Raffaele Scientific Institute in Milan.
Filippi and his researchers used magnetic resonance imaging (MRI) to do brain images from 63 migraine patients and 18 healthy controls. They were able to estimate cortical thickness and surface area and correlated it with the patients’ clinical and radiologic characteristics.
“Compared to controls, migraine patients showed reduced cortical thickness and surface area in regions related to pain processing,” the press release said.
“There was only minimal anatomical overlap of cortical thickness and cortical surface area abnormalities, with cortical surface area abnormalities being more pronounced and distributed than cortical thickness abnormalities. The presence of aura and white matter hyperintensities — areas of high intensity on MRI that appear to be more common in people with migraine —was related to the regional distribution of cortical thickness and surface area abnormalities, but not to disease duration and attack frequency.”
Filippi said, “The most important finding of our study was that cortical abnormalities that occur in patients with migraine are a result of the balance between an intrinsic predisposition, as suggested by cortical surface area modification, and disease-related processes, as indicated by cortical thickness abnormalities.”
According to the doctor, “Accurate measurements of cortical abnormalities could help characterize migraine patients better and improve understanding of the pathophysiological processes underlying the condition.”
He added that additional research is needed to fully understand the meaning of cortical abnormalities in the pain processing areas of migraine patients.
“Whether the abnormalities are a consequence of the repetition of migraine attacks or represent an anatomical signature that predisposes to the development of the disease is still debated,” he said.
“In my opinion, they might contribute to make migraine patients more susceptible to pain and to an abnormal processing of painful conditions and stimuli.”
The researchers are conducting a longitudinal study of the patient group to see if their cortical abnormalities are stable or tend to worsen over the course of the disease.
They are also studying the effects of treatments on the observed modifications of cortical folding and looking at pediatric patients with migraine to assess whether the abnormalities represent a biomarker of the disease.